Jesse Poganik, PhD

I am an Investigator at Brigham and Women's Hospital and Instructor in Medicine at Harvard Medical School in Boston, MA, USA.

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Biomarkers of Aging Consortium

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02/2025: A short commentary I co-authored with Mahdi Moqri, Steve Horvath, and Vadim Gladyshev on factors driving epigenetic clock signals was published in Nature Aging.

What makes biological age epigenetic clocks tick - Nature Aging

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02/2025: I was quoted in Nicoletta Lanese's article "Biological aging may not be driven by what we thought" in LiveScience.

Biological aging may not be driven by what we thoughtA new study draws a line between random genetic mutations and predictable epigenetic changes used to measure biological aging.

12/2024: I organized a breakout session titled "Innovative tools and approaches for studying the biology of aging at the Broad" at the Broad's 20th Scientific Retreat. We featured talks from Vadim Gladyshev, Aoxing Liu, Jonathan Gootenberg, Omar Abudayyeh, and Mahdi Moqri. Thank you to Sinéad Chapman for championing this session!

12/2024: It was a pleasure to return to the Longevity Summit at the Buck Institute this year to give an update on the work of the Biomarkers of Aging Consortium.

11/2024: It was a pleasure to speak at the Future of Aging Research 2024 Mixer, organized by the Aging Initiative at Harvard.

11/2024: The 2024 Biomarkers of Aging Conference was a huge success! It was great to share two amazing days with over 450 colleagues at HMS.

10/2024: I spoke at the "Interdisciplinary Discussion on How Can AI Transform Aging Research” organized by the Harvard Graduate Student Club, Interdisciplinary Discussion on Disease and Health, organized by Albert Ying and colleagues. Themes from this event were published in the World Economic Forum.

09/2024: The 3rd collaborative manuscript of the Biomarkers of Aging Consortium was published in Nature Aging. Tori Roberts from MGB Communications prepared a nice summary based on an interview with me.

Challenges and recommendations for the translation of biomarkers of aging - Nature AgingBiomarkers of aging have potential to accelerate the clinical translation of interventions that promote healthy aging but are currently limited to research. The authors identify six barriers to be overcome to enable biomarker translation, providing a roadmap to clinical implementation.

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Research Spotlight: Addressing Challenges to Clinical Translation of Biomarkers of Aging Tools - Brigham Clinical & Research NewsJesse R. Poganik, PhD, an Instructor in Medicine in the Division of Genetics at Brigham and Women’s Hospital, is a…

08/2024: I spoke at the 11th Aging Research and Drug Design (ARDD) conference in Copenhagen, Denmark.

07/2024: I was quoted in Lisa Rappaport's article on biological age tests in Everyday Health.

Biological Age Tests: How They Work and if They’re LegitimateCan a blood draw, cheek swab, or urine sample really tell you if you’re younger (or older) than the number of your birthdays? Here’s what to know about these popular wellness products, and whether they are helpful.

06/2024: I spoke at the second Systems Aging GRC in Barcelona, Spain.

05/2024: I gave back-to-back talks on our recent work and the consortium at the Longevity Med Summit in Lisbon, Portugal, and the virtual Systems Biology of Aging Workshop hosted by the Institute for Systems Biology.

04/2024: Mahdi and I joined Longevity Global's new Boston Chapter at their first meetup to discuss biomarkers of aging.

03/2024: I was quoted in a STAT article describing a great new study in Cell Metabolism that independently replicated and extended our discovery of transient biological age elevation during pregnancy.

Pregnancy increases biological age — but recovery and breastfeeding can undo the damage, study findsPregnancy increases biological age — but recovery and breastfeeding can undo the damage, study finds.

03/2024: Brigham Clinical & Research News wrote a really nice article about aging research across BWH, featuring quotes from Jessica Lasky-Su, Vadim Gladyshev, Mahdi Moqri, and me.

Unlocking the Clock: How Brigham Scientists Are Capturing the Way We Age - Brigham Clinical & Research NewsEvery day, you’re one day older, right? Not necessarily. Brigham researchers may soon be able to tell you your biological…

03/2024: Rebecca Kranz of What A Year, a publication of the Massachusetts Society for Medical Research aimed at middle and high school students, prepared a nice write up of a recent interview with me, Bohan Zhang, and Vadim Gladyshev.

02/2024: The second publication of the Biomarkers of Aging Consortium on validation of aging biomarkers was published in Nature Medicine!

Validation of biomarkers of aging - Nature MedicineRobust validation of biomarkers of aging will be critical to their clinical translation; here, authors review the key challenges and propose recommendations to overcome them.

02/2024: I was quoted in Dr. Ken Springer's Statisfied Substack.
02/2024: Mahdi and I spoke about our research and the work of the consortium at the Boston Computational Biology Society's webinar on February 1. See the recording here (password: PxY8H+A0).

01/2024: Longevity.Technology wrote an excellent recap of our Biomarkers of Aging Symposium held last December:

'Biomarkers of aging – the momentum is palpable'The inaugural Biomarkers of Aging Symposium signposts an optimistic future for the field, say the organizers.

12/2023: I was quoted in Dana Smith's article on biological age testing in the New York Times:

What’s Your ‘Biological Age’?New tests promise to tell you if you have the cells of a 30-year-old or a 60-year-old. Here’s what to know about them.

12/2023: Our Cell Metabolism paper on biological age fluctuations was listed as a piece of top performing research from BWH in 2023:

Research Wrapped - Brigham Clinical & Research News2023 was a year of many milestones in medical research, including research-driven clinical advances that are yielding new treatments for…

12/2023: Our work on biological age fluctuations ("The Promising Weirdness of Biological Age") was featured in the Harvard Gazette's 2023 Highlights:

Looking back on another year of discovery at Harvard — Harvard GazetteResearch in 2023 yielded insights on drinking, sleep, guns, longevity, and whether the good old days really were.

12/2023: Mahdi and I appeared on the VitaDao podcast to discuss the Biomarkers of Aging Consortium:

Aging Insights: Dr. Jesse Poganik and Dr. Mahdi Moqri on Biomarkers and Longevity Research – The VitaDAO Aging Science PodcastIn the upcoming episode of The Science of Aging Podcast, we're set to explore aging research with Dr. Jesse Poganik and Dr. Mahdi Moqri, just before the 2023 Biomarkers of Aging Symposium. Dr. Poganik ...

12/2023: We had a fantastic inaugural Biomarkers of Aging Symposium at the beautiful Buck Institute. Thanks to everyone who came! We are looking forward to next year's conference at HMS in Boston, November 1–2, 2024.

11/2023: Mahdi Moqri and I appeared on the National University of Singapore's Centre for Healthy Longevity Webinar series to promote the work of the Biomarkers of Aging Consortium:

09/2023: An opinion piece I co-authored with Vadim was published in PNAS! We lay out the case for grappling with the most foundational features of the aging process, namely the essence and biological nature of aging, as a way to accelerate progress in our exciting and important field.

08/2023: Longevity.Technology covered the Consortium's first manuscript and included comments from Mahdi, Vadim, and me:

Brigham researchers offer cohesive framework for evaluating biomarkers of agingNew paper documents framework for the classification and evaluation of biomarkers of aging and lays groundwork for future longevity advances.

08/2023: The inaugural collaborative manuscript of the Biomarkers of Aging Consortium was published in Cell! This manuscript presents a framework for the evaluation of aging biomarkers.

06/2023: Two methods papers on Z-REX, a platform I contributed to establishing in zebrafish during my PhD, were published in Nature Protocols and JoVE.

- 04/2023: Our paper on biological age fluctuations in response to severe physiological stress was published in Cell Metabolism!
- See news and social media coverage here:

03/2023: I spoke to Hannah Went on the Everything Epigenetics podcast about our recent work and the future of epigenetic aging biomarkers. You can find this on Youtube, Spotify, Apple Podcasts, and other streaming platforms.

03/2023: I am excited to be serving on the Executive Committee of the newly launched Biomarkers of Aging Consortium. This important effort is aimed at cultivating consensus in the aging field to develop robust biomarkers of aging. Learn more at the consortium website and in this interview with Dr. Mahdi Moqri, who conceived the idea for the consortium and has been its main driving force.
12/2022: I spoke with Jim Mora of Radio New Zealand about our recent work on biological aging: Link
10/2022: You can watch a talk I gave at Metabesity 2022 here (my talk starts around 36:00): Link
10/2022: A manuscript I collaborated on during my PhD was published in eLife. We ascribed differential functions to the two zebrafish paralogs of the stress sensor protein Keap1: Link
05/2022: Lifespan.io wrote a great summary of our work on stress and aging: Link
05/2022: Our preprint on transient changes in biological age is available on BioRxiv: Link